Toll-like Receptors are Key Participants in Innate Immune Responses

ARANCIBIA, SERGIO A; Beltrán, Caroll J; AGUIRRE, ISABEL M; Silva, Paulina; PERALTA, ALEXIS L; Malinarich, Frano; Hermoso, Marcela A

Keywords: cytokines, innate immunity, toll-like receptors, myd88, nfkb


During an infection, one of the principal challenges for the host is to detect the pathogen and activate a rapid defensive response. The Toll-like family of receptors (TLRs), among other pattern recognition receptors (PRR), performs this detection process in vertebrate and invertebrate organisms. These type I transmembrane receptors identify microbial conserved structures or pathogen-associated molecular patterns (PAMPs). Recognition of microbial components by TLRs initiates signaling transduction pathways that induce gene expression. These gene products regulate innate immune responses and further develop an antigen-specific acquired immunity. TLR signaling pathways are regulated by intracellular adaptor molecules, such as MyD88, TIRAP/Mal, between others that provide specificity of individual TLR- mediated signaling pathways. TLR-mediated activation of innate immunity is involved not only in host defense against pathogens but also in immune disorders. The involvement of TLR-mediated pathways in auto-immune and inflammatory diseases is described in this review article

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Título según WOS: Toll-like receptors are key participants in innate immune responses
Título según SCIELO: Toll-like Receptors are Key Participants in Innate Immune Responses
Título de la Revista: BIOLOGICAL RESEARCH
Volumen: 40
Número: 2
Fecha de publicación: 2007
Página de inicio: 97
Página final: 112
Idioma: en