Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and Controls

Herrera, Christian L.; Jaramillo, Priscilla C; Lanas, Fernando; Salazar, Luis A.

Abstract

"The platelet endothelial cell adhesion molecule-1 (PECAM-1), a 130-kDa membrane glycoprotein, is expressed on the surface of monocytes, some T-lymphocyte subsets, neutrophils, platelets and endothelial cells. PECAM-1 plays a key role in the transendothelial migration of circulating leukocytes during vascular inflammation. The aim of the present investigation was to evaluate the association between the C373G polymorphism of the PECAM-1 gene and coronary artery disease in Chilean subjects. A total of 220 individuals were investigated (112 cases and 108 controls). The presence of coronary artery disease was confirmed by angiography (Stenosis >70%). The C373G polymorphism was detected by polymerase chain reaction followed enzymatic restriction. The genotype frequencies were in agreement with those predicted by the Hardy-Weinberg equilibrium in both groups. The genotype distribution and the relative al

Más información

Título según SCOPUS: Polymorphism C373G of the PECAM-1 gene in Chilean subjects with coronary disease and controls
Título según SCIELO: Polymorphism C373G of the PECAM-1 Gene in Chilean Subjects with Coronary Disease and Controls
Título de la Revista: International Journal of Morphology
Volumen: 25
Número: 2
Editorial: Sociedad Chilena de Anatomía
Fecha de publicación: 2007
Página de inicio: 439
Página final: 444
Idioma: en
URL: http://www.scielo.cl/scielo.php?script=sci_arttext&pid=S0717-95022007000200031&lng=en&nrm=iso&tlng=en
DOI:

10.4067/S0717-95022007000200031

Notas: SCIELO, SCOPUS