Oxidative Stress and Autophagy in Cardiovascular Homeostasis

Morales C.R.; pedrozo, Z; Lavandero S.; Hill J.A.


Significance: Autophagy is an evolutionarily ancient process of intracellular protein and organelle recycling required to maintain cellular homeostasis in the face of a wide variety of stresses. Dysregulation of reactive oxygen species (ROS) and reactive nitrogen species (RNS) leads to oxidative damage. Both autophagy and ROS/RNS serve pathological or adaptive roles within cardiomyocytes, depending on the context. Recent Advances: ROS/RNS and autophagy communicate with each other via both transcriptional and post-translational events. This cross talk, in turn, regulates the structural integrity of cardiomyocytes, promotes proteostasis, and reduces inflammation, events critical to disease pathogenesis. Critical Issues: Dysregulation of either autophagy or redox state has been implicated in many cardiovascular diseases. Cardiomyocytes are rich in mitochondria, which make them particularly sensitive to oxidative damage. Maintenance of mitochondrial homeostasis and elimination of defective mitochondria are each critical to the maintenance of redox homeostasis. Future Directions: The complex interplay between autophagy and oxidative stress underlies a wide range of physiological and pathological events and its elucidation holds promise of potential clinical applicability. Antioxid. Redox Signal. 20, 507-518.

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Título según WOS: Oxidative Stress and Autophagy in Cardiovascular Homeostasis
Volumen: 20
Número: 3
Editorial: Mary Ann Liebert Inc.
Fecha de publicación: 2014
Página de inicio: 507
Página final: 518
Idioma: English
URL: http://online.liebertpub.com/doi/abs/10.1089/ars.2013.5359


Notas: ISI