A risk prediction model for severe intraventricular hemorrhage in very low birth weight infants and the effect of prophylactic indomethacin

Luque, MJ; Tapia, JL; Villarroel L.; Marshall G.; Musante, G.; Carlo, W; Kattan J.

Abstract

OBJECTIVE: Develop a risk prediction model for severe intraventricular hemorrhage (IVH) in very low birth weight infants (VLBWI). STUDY DESIGN: Prospectively collected data of infants with birth weight 500 to 1249 g born between 2001 and 2010 in centers from the Neocosur Network were used. Forward stepwise logistic regression model was employed. The model was tested in the 2011 cohort and then applied to the population of VLBWI that received prophylactic indomethacin to analyze its effect in the risk of severe IVH. RESULT: Data from 6538 VLBWI were analyzed. The area under ROC curve for the model was 0.79 and 0.76 when tested in the 2011 cohort. The prophylactic indomethacin group had lower incidence of severe IVH, especially in the highest-risk groups. CONCLUSION: A model for early severe IVH prediction was developed and tested in our population. Prophylactic indomethacin was associated with a lower risk-adjusted incidence of severe IVH.

Más información

Título según WOS: A risk prediction model for severe intraventricular hemorrhage in very low birth weight infants and the effect of prophylactic indomethacin
Título de la Revista: JOURNAL OF PERINATOLOGY
Volumen: 34
Número: 1
Editorial: Nature Publishing Group
Fecha de publicación: 2014
Página de inicio: 43
Página final: 48
Idioma: English
URL: http://www.nature.com/doifinder/10.1038/jp.2013.127
DOI:

10.1038/jp.2013.127

Notas: ISI