Levels of inflammatory cytokines and plasma cortisol in respiratory syncytial virus bronchiolitis
Abstract
Background: An increased inflammatory innate response may play a role in pathogenesis of respiratory syncytial virus (RSV) infection. Aim: To quantify pro-inflammatory cytokines (IL-6-IL-8, IL-1-beta and TNF-alpha) in nasopharyngeal aspirate (NPA) and plasma, and plasma cortisol in previously healthy infants with RSV bronchiolitis. Patients and Methods: We studied 49 infants aged less than one year of age with RSV bronchiolitis and 25 healthy controls. Severity was defined using a previously described modified score. We quantified interleukins in NPA and plasma by flow cytometry and plasma cortisol by radioimmunoanalysis. Results: Among patients with RSV bronchiolitis, 25 were classified as severe and 24 as moderate or mild. Significantly higher levels of IL-6 and IL-8 in NPA and plasma and IL-1 beta in NPA were found in children classified as severe, when compared to those with moderate or mild disease and controls. There was a positive correlation between IL-6 and cortisol in plasma (r = 0,55; p < 0,0001) and both were correlated with the severity of the disease. Conclusions: RSV bronchiolitis severity was associated with higher levels of inflammatory interleukins and plasma cortisol.
Más información
Título según WOS: | Levels of inflammatory cytokines and plasma cortisol in respiratory syncytial virus bronchiolitis |
Título de la Revista: | REVISTA MEDICA DE CHILE |
Volumen: | 141 |
Número: | 5 |
Editorial: | Sociedad Médica de Santiago |
Fecha de publicación: | 2013 |
Página de inicio: | 574 |
Página final: | 581 |
Idioma: | Spanish |
Notas: | ISI |