In vitro cell response to chemotherapeutic agents, to personalize ovarian cancer treatment. Report of two cases

Ibáñez C; Garrido M.; Medina, L; Kato, S; Bravo, ML; Gonzalez P.; Oliva, B.; Pizarro J.; Bustamante, E; Brañes J.; Cuello, M.; Owen, GI

Abstract

Our laboratory has implemented an in vitro assay to estimate the response to chemotherapy in ovarian cancer cells pertaining to individual patients. In two selected patients, we determined the correlation between an in vitro assay of cells from suspected ovarian cancer ascites, with the clinical chemotherapy response. Cancer cells isolated from peritoneal fluid with suspected ovarian cancer were tested for cytotoxicity with corresponding chemotherapy regimens. Circulating Ca125 levels and attending physician consultation determined clinical course and response to chemotherapy. The in vitro assay result correlated with Ca125 levels, progression free survival and attending physician evaluation. The assay predicted correctly the failure of two successive chemotherapy regimes in the first patient, while predicting a favorable clinical response in the second subject.

Más información

Título según WOS: In vitro cell response to chemotherapeutic agents, to personalize ovarian cancer treatment. Report of two cases
Título de la Revista: Revista Médica de Chile
Volumen: 141
Número: 5
Editorial: Sociedad Médica de Santiago
Fecha de publicación: 2013
Página de inicio: 669
Página final: 673
Idioma: Spanish
Notas: ISI