An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G(2)/M-phase arrest in mammary adenocarcinoma TA3

Urra, FA; Martinez-Cifuentes, M; Pavani, M.; Lapier, M.; Jana-Prado, F; Parra E.; Maya, JD; Pessoa-Mahana H.; Ferreira J.; Araya-Maturana, R

Abstract

Tumor cells present a known metabolic reprogramming, which makes them more susceptible for a selective cellular death by modifying its mitochondrial bioenergetics. Anticancer action of the antioxidant 9,10-dihydroxy-4,4-dimethy1-5,8-dihydroanthracen-1(4H)-one (HQ) on mouse mammary adenocarcinoma TA3, and its multiresistant variant TA3-MTXR, were evaluated. HQ decreased the viability of both tumor cells, affecting slightly mammary epithelial cells. This hydroquinone blocked the electron flow through the NADH dehydrogenase (Complex I), leading to ADP-stimulated oxygen consumption inhibition, transmembrane potential dissipation and cellular ATP level decrease, without increasing ROS production. Duroquinol, an electron donor at CoQ level, reversed the decrease of cell viability induced by HQ. Additionally, HQ selectively induced G(2)/M-phase arrest Taken together, our results suggest that the bioenergetic dysfunction provoked by HQ is implicated in its anticancer action. (c) 2013 Elsevier Inc. All rights reserved.

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Título según WOS: An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G(2)/M-phase arrest in mammary adenocarcinoma TA3
Título según SCOPUS: An ortho-carbonyl substituted hydroquinone derivative is an anticancer agent that acts by inhibiting mitochondrial bioenergetics and by inducing G2/M-phase arrest in mammary adenocarcinoma TA3
Título de la Revista: TOXICOLOGY AND APPLIED PHARMACOLOGY
Volumen: 267
Número: 3
Editorial: ACADEMIC PRESS INC ELSEVIER SCIENCE
Fecha de publicación: 2013
Página de inicio: 218
Página final: 227
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0041008X13000136
DOI:

10.1016/j.taap.2012.12.023

Notas: ISI, SCOPUS