¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE
Abstract
"N-(3-(1H-Imidazol-1-yl)propyl)-2-phenylquinazolin-4-amine (2) was obtained by nucleophilic substitution of 1-(3-aminopropyl)-imidazole over 4-chloro-2-phenylquinazoline (1) with DMF/TEA at room temperature. The precursor and product were characterized by NMR spectroscopy. The structure of the title compound was confirmed by X-ray diffraction methods. The quinazoline fragment (2) is essentially planar and makes a dihedral angle of 66.35 ° with the imidazole plane. In the crystal packing the molecules are associated by two strong intermolecular NH----N hydrogen bonds with graph-set motif R²2(16). These pairs are linked by two π-π interactions."
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Título según SCIELO: | �H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE |
Título de la Revista: | JOURNAL OF THE CHILEAN CHEMICAL SOCIETY |
Volumen: | 58 |
Número: | 2 |
Editorial: | SOC CHILENA QUIMICA |
Fecha de publicación: | 2013 |
Página de inicio: | 1771 |
Página final: | 1774 |
Idioma: | en |
DOI: |
10.4067/S0717-97072013000200029 |
Notas: | SCIELO |