¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE

PÉREZ-FEHRMANN, MARCIA; Kesternich, Victor; Verdugo, Felipe; Marcourt, Laurence; Christen, Philippe; Brito, Ivan

Abstract

"N-(3-(1H-Imidazol-1-yl)propyl)-2-phenylquinazolin-4-amine (2) was obtained by nucleophilic substitution of 1-(3-aminopropyl)-imidazole over 4-chloro-2-phenylquinazoline (1) with DMF/TEA at room temperature. The precursor and product were characterized by NMR spectroscopy. The structure of the title compound was confirmed by X-ray diffraction methods. The quinazoline fragment (2) is essentially planar and makes a dihedral angle of 66.35 ° with the imidazole plane. In the crystal packing the molecules are associated by two strong intermolecular NH----N hydrogen bonds with graph-set motif R²2(16). These pairs are linked by two π-π interactions."

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Título según SCIELO: ¹H AND 13C NMR SPECTRAL ASSIGNMENTS AND X-RAY CRYSTALLOGRAPHY OF N-(3-(1H-IMIDAZOL-1-YL)PROPYL)-2-PHENYLQUINAZOLIN-4-AMINE
Título de la Revista: Journal of the Chilean Chemical Society
Volumen: 58
Número: 2
Editorial: Sociedad Chilena de Química
Fecha de publicación: 2013
Página de inicio: 1771
Página final: 1774
Idioma: en
DOI:

10.4067/S0717-97072013000200029

Notas: SCIELO