The inhibitory effects of squalene-derived triterpenes on protein phosphatase PP2A.

Souto ML1, Manríquez CP, Norte M, Leira F, Fernández JJ.


This paper reports testing 15 polyether triterpenes with a squalene carbon skeleton for inhibitory effects on type 2A protein phosphatase. Two compounds, 16-hydroxydehydrothyrsiferol 10 and thyrsenol B 14, exhibited significant inhibitory action at a concentration of 10 microM. Comparison with thyrsiferyl-23-acetate 1 showed that a similar spatial disposition for the hydroxy group around C-15 or C-16 was the structural feature shared by these metabolites.

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Título de la Revista: Bioorg Med Chem Lett
Volumen: 13
Número: 7
Fecha de publicación: 2002
Página de inicio: 1261
Página final: 1264