Maraviroc does not affect humoral response to the pandemic influenza A-H1N1v 2009 adjuvanted vaccine in HIV-1-infected patients

Canestri A, Krivine A, Assoumou L, Le Corre Monique, Rozenberg F, Marcelin AG, Schneider L, Samri A, Carcelain G, Autran B, Katlama C, Guihot A

Abstract

Immune changes induced by the CCR5 antagonist maraviroc raise the question of an impairment of responses to vaccines. We evaluated the immunogenicity of the adjuvanted pandemic influenza A-H1N1v 2009 vaccine in HIV-1-infected patients with suppressed HIV viremia with or without a maraviroc-containing regimen. Seroprotection, seroconversion, and geometric mean titer ratio of specific antibody titers did not differ between groups. These results suggest that maraviroc does not significantly affect the immune response to this adjuvanted vaccine. Copyright © Lippincott Williams & Wilkins.

Más información

Título según SCOPUS: Maraviroc does not affect humoral response to the pandemic influenza A-H1N1v 2009 adjuvanted vaccine in HIV-1-infected patients
Título de la Revista: AIDS
Volumen: 24
Número: 18
Editorial: LIPPINCOTT WILLIAMS & WILKINS
Fecha de publicación: 2010
Página de inicio: 2887
Página final: 2889
Idioma: English
DOI:

10.1097/QAD.0b013e3283402bc1

Notas: SCOPUS