Novel physiological and therapeutic implications of leptin

Goldenberg D.; Santos, JL; Hodgson, MI; Cortes, VA


The adipose tissue is an endocrine organ that produces a variety of protein hormones. One of them is leptin, which regulates several critical functions at the central nervous system such as caloric intake, basal energy expenditure, reproduction, glucose and lipid metabolism and osteogenesis. Acting at a local level, leptin modulates the immune system and promotes liver fibrogenesis. The most promising therapeutic implications of leptin will possibly be in type 1 diabetes mellitus (DM1). Its supplementation in animal models of DM1 prevents hyperglycemia and ketoacidosis. These actions depend on the activation of leptin receptors in the central nervous system and the suppression of glucagon signaling in the liver.

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Título según WOS: Novel physiological and therapeutic implications of leptin
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 142
Número: 6
Editorial: Sociedad Médica de Santiago
Fecha de publicación: 2014
Página de inicio: 738
Página final: 747
Idioma: Spanish
Notas: ISI