Association between obesity and ovarian cancer

Valladares, M; Corsini, G; Romero C.


Obesity is a risk factor for cancer. Epidemiological evidences associate ovarian cancer with obesity. Epithelial ovarian cancer (EOC) is the most common type of ovarian cancer and accounts for a high rate of mortality. The association between ovarian cancer and obesity could be explained by molecular factors secreted by adipose tissue such as leptin. In EOC, leptin increases cell proliferation and inhibits apoptosis. Additionally, adipose tissue synthesizes endogenous estrogens, which increase cell proliferation of epithelial ovarian cells. Also, obesity associated hyperinsulinism could increase ovarian estrogen secretion.

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Título según WOS: Association between obesity and ovarian cancer
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 142
Número: 5
Fecha de publicación: 2014
Página de inicio: 593
Página final: 598
Idioma: Spanish
Notas: ISI