Human Papilloma Virus Frequency in non-Gynecological Tumors in the Araucania Region, Chile

Hoffstetter R; Andana, A; Guzman P.; Ili CG; Retamal J.; Mora B.; Roa, JC; Sanchez R.

Keywords: human papillomavirus, Esophageal neoplasm, Prostate neoplasm, Reverse line blot - assay


Human Papilloma Virus (HPV) is the most common sexually transmitted disease in the world and it is present in practically all cervical cancers. Its presence was described in other types of non-gynecologic cancer such as esophageal and prostate. However, HPV frequency described for these cancers is highly variable, and there are no articles describing the presence of HPV in these tumors in Chile. To determine HPV frequency in samples from biopsies of non-gynecological tumors and inflammatory tissue from patients in the Araucania region, DNA was extracted from a total of 47 biopsies from patients with esophagitis, 25 with esophageal squamous cell carcinoma, 20 with prostate nodular hyperplasia and 39 with prostate adenocarcinoma. These were analyzed by PCR of HPV L1 region and subsequent genotyping by reverse line blot. HPV was detected in 53.2% of esophagitis samples, 48% in esophageal squamous cell carcinoma, 15% in prostatitis and 15.4% in cases of prostatic adenocarcinoma. The most frequent HPV genotypes were 16 and 18, either single or in combination with other genotype infections, in inflammatory tissue and neoplastic lesions. In patients of the Araucania region, there is a high rate of HPV infection in biopsies obtained in esophagitis and esophageal inflammatory tissue. In cases of prostatic adenocarcinoma and prostate nodular hyperplasia a low rate of HPV was observed.

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Título según WOS: Human Papilloma Virus Frequency in non-Gynecological Tumors in the Araucania Region, Chile
Volumen: 32
Número: 4
Editorial: In Press.
Fecha de publicación: 2014
Página de inicio: 1254
Página final: 1260
Idioma: Spanish
Notas: ISI