Autophagy meets fused in sarcoma-positive stress granules

Matus, Soledad; Bosco, Daryl A.; Hetz, Claudio


Mutations in fused in sarcoma and/or translocated in liposarcoma (FUS, TLS or FUS) are linked to familial cases of amyotrophic lateral sclerosis (ALS). Mutant FUS selectively accumulates into discrete cytosolic structures known as stress granules under various stress conditions. In addition, mutant FUS expression can alter the dynamics and morphology of stress granules. Although the link between mutant FUS and stress granules is well established, the mechanisms modulating stress granule formation and disassembly in the context of ALS are poorly understood. In this issue of Neurobiology of Aging, Ryu et al. uncover the impact of autophagy on the potential toxicity of mutant FUS-positive stress granules. The authors provide evidence indicating that enhanced autophagy activity reduces the number of stress granules, which in the case of cells containing mutant FUS-positive stress granules, is neuroprotective. Overall, this study identifies an intersection between the proteostasis network and alterations in RNA metabolism in ALS through the dynamic assembly and disassembly of stress granules. (C) 2014 Elsevier Inc. All rights reserved.

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Título según WOS: Autophagy meets fused in sarcoma-positive stress granules
Título según SCOPUS: Autophagy meets fused in sarcoma-positive stress granules
Título de la Revista: NEUROBIOLOGY OF AGING
Volumen: 35
Número: 12
Editorial: Elsevier Science Inc.
Fecha de publicación: 2014
Página de inicio: 2832
Página final: 2835
Idioma: English