Neurobehavioral and autonomic alterations in adults with obstructive sleep apnea

Idiáquez J.; Santos, I.; Santin J.; Del Rio R.; Iturriaga R.

Keywords: obstructive sleep apnea, autonomic dysfunction, heart rate variability, Cognitive dysfunction tests, Night sweating

Abstract

Objective: Obstructive sleep apnea (OSA) is associated with sympathetic hyperactivity, excessive nocturnal sweating, sleepiness, and neurobehavioral cognitive alterations. However, it is not well known if cognitive consequences of OSA are independent from autonomic alterations. Thus, we assessed the association between polysomnographic, autonomic, and cognitive tests performance in OSA patients. Methods: Fifty eight OSA patients (53 male) were administered with questionnaires assessing demographic, Epworth, Beck Depression Inventory, Syndrom Kurz test (SKT), Trail Making part B (TMT-B), and Frontal Assessment Battery (FAB) tests. Spectral analysis of heart rate variability (HRV) and night sweating symptoms (NSwS) score were used to assess autonomic function. Results: Global cognitive function (SKT) was normal in mild-moderate (M-OSA) and severe (S-OSA) patients. In S-OSA patients AHI was correlated with TMT-B (r = 0.30 P < 0.05) and with FAB (r = -0.31 P < 0.05). Oxygen desaturation was correlated with TMT-B (r = -0.45 P = < 0.001) and FAB (r = 0.29 P = < 0.05). Sympathetic overactivity was correlated with oxygen desaturation: HRV (r = -0.39 P < 0.05) and NSwS score (r = -0.49 P < 0.01), but HRV and NSwS score were not correlated with TMT-B and FAB. Conclusion: Frontal cognitive dysfunction and predominance of sympathetic drive occur in OSA patients. Abnormal frontal cognitive function and sympathetic hyperactivity were related to oxygen desaturation, but not between each other. We conclude that neurobehavioral changes and autonomic imbalance in OSA patients take place independently from each other, suggesting different pathophysiological pathways. (C) 2014 Elsevier B.V. All rights reserved.

Más información

Título según WOS: Neurobehavioral and autonomic alterations in adults with obstructive sleep apnea
Título según SCOPUS: Neurobehavioral and autonomic alterations in adults with obstructive sleep apnea
Título de la Revista: SLEEP MEDICINE
Volumen: 15
Número: 11
Editorial: ELSEVIER SCIENCE BV
Fecha de publicación: 2014
Página de inicio: 1319
Página final: 1323
Idioma: English
DOI:

10.1016/j.sleep.2014.05.030

Notas: ISI, SCOPUS