The vertebrate muscle-specific RING finger protein family includes MuRF4-A novel, conserved E3-ubiquitin ligase

Macqueen, DJ; Fuentes, EN; Valdes, JA; Molina A.; Martin, SAM

Keywords: evolution, striated muscle, retrotransposition, Muscle-specific RING finger family, Novel MuRF: MuRF4, E3-ubiquitin ligase

Abstract

Muscle-specific RING finger (MuRF) proteins are E3-ubiquitin ligases and key regulators of muscle growth and turnover. Here, using a range of phylogenomic approaches, we established the complete-definitive MuRF family of vertebrates. Adding to recognized MuRF1, 2 and 3, we describe a novel family member, hereafter MuRF4, which was independently lost during placental mammal and bird evolution, but is otherwise conserved. MuRF4 transcripts were expressed in heart and skeletal muscles of zebrafish, but were barely detectable in striated muscles of adult anole lizards. We also demonstrate that MuRF1 underwent retrotransposition in the teleost fish ancestor, before the retrogene fully replaced the original gene and muscle-specific function. (C) 2014 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

Más información

Título según WOS: The vertebrate muscle-specific RING finger protein family includes MuRF4-A novel, conserved E3-ubiquitin ligase
Título según SCOPUS: The vertebrate muscle-specific RING finger protein family includes MuRF4 - A novel, conserved E3-ubiquitin ligase
Título de la Revista: FEBS LETTERS
Volumen: 588
Número: 23
Editorial: ELSEVIER SCIENCE BV
Fecha de publicación: 2014
Página de inicio: 4390
Página final: 4397
Idioma: English
DOI:

10.1016/j.febslet.2014.10.008

Notas: ISI, SCOPUS