Sonothrombolysis for acute ischemic stroke

Brunser, A.; Hoppe, A; Muñoz P; Carcámo D.; Lavados, PM; Gaete, J; Roldan A.; Rivas, R

Keywords: therapy, stroke, thrombolytic therapy, Ultrasonography, Doppler


Background: Sonothrombolysis (ST) is an emerging modality for the treatment of stroke. Aim: To assess the feasibility to perform ST in a Chilean hospital. Material and Methods: Patients attended at a private clinic with an acute ischemic stroke, between September 2002 and May 2013 and eligible for endovenous thrombolysis, were studied with a transcranial Doppler (Spencer PMD 100 or 150 (R)). Those with an adequate sonographic window and a demonstrated arterial occlusion were monitored continuously with transcranial Doppler at the site of worst residual flow following the CLOTBUST study protocol. Results: One thousand twenty six patients were studied, of whom 136 received intravenous thrombolysis (rt-PA) and 61, aged 66 +/- 18 years (59% males), were subjected to ST (7% of total). Their median National Institutes of Health Stroke Scale score was 14, the lapse from symptom onset to rt-PA was 127 minutes (43-223). Middle cerebral artery (MCA) occlusion was found in 88.5% of patients. Complete recanalization was achieved in 44.3% of patients. Sixty percent had Modified Rankin Scale of 0 to 2 at 3 months (95% confidence intervals (CI) 48.1 to 72). Case fatality was 9.8% and asymptomatic intracranial hemorrhage occurred in 9.8% (95% CI: 4.3 to 20.2). Conclusions: ST can be carried out in a complex medical center and is safe.

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Título según WOS: Sonothrombolysis for acute ischemic stroke
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 142
Número: 10
Fecha de publicación: 2014
Página de inicio: 1238
Página final: 1244
Idioma: Spanish
Notas: ISI