Treatment of diabetic ketoacidosis using 2009 American Diabetes Association guidelines

Olmos, P; Donos, A; Arab, JP; Niklitschek, I; Mertens N.; Arce, E; Lemus R; Serrano, V; Grassi, B; Strodthoff, K; Abbott E.; Aizman A.; Gonzalez, MV

Keywords: diabetes mellitus, diabetic ketoacidosis


Background: During 2009, new guidelines for the treatment of diabetic ke'toacidosis were published by the American Diabetes Association. Aim: To assess the impact of new treatment guidelines on the evolution of patients treated for diabetic ketoacidosis (KAD). Patients and Methods: Anonymous data was obtained from computational medical records of patients treated for KAD at our institution two years before (Traditional Protocol) and TWO years after (ADA-2009 Protocol) the publication of the 2009 American Diabetes Association (ADA) KAD guidelines. Results: Twenty three patients aged 36.5 +/- 15.1 years were treated with the traditional method and 23 patients aged 44.4 +/- 21.1 years were treated following 2009 ADA guidelines. Among patients treated with the traditional protocol and treated following ADA 2009 guidelines, the diabetes type 1/type 2 ratio was18/5 and 19/16 respectively (p = NS), the glycosylated hemoglobin on admission was 12.6 +/- 2.5 and 14.3 +/- 2.7% respectively (p = 0.03), minimal blood pH was 7.15 +/- 0.14 and 7.19 +/- 0.09 respectively (p = NS), bicarbonate was required in seven and no patient respectively (p = 0.01), hypokalemia < 3.5 mEq/L occurred in 78.2 and 48.5% of patients (p = 0.03), the lapse until resolution was 28.7 +/- 28.0 and 28.8 +/- 20.6 hours (p = NS). Only one patient, treated following ADA 2009 guidelines, died. Conclusions: Introduction of the ADA-2009 protocol for the treatment of KAD resulted in decrease in the use of intravenous bicarbonate and a reduction in the incidence of hypokalemia. There was no impact neither in the lapse until resolution or lethality.

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Título según WOS: Treatment of diabetic ketoacidosis using 2009 American Diabetes Association guidelines
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 142
Número: 10
Editorial: Sociedad Médica de Santiago
Fecha de publicación: 2014
Página de inicio: 1267
Página final: 1274
Idioma: Spanish
Notas: ISI