Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines

Montenegro I.; Tomasoni, G; Bosio, C; Quinones, N; Madrid, A; Carrasco H.; Olea A.; Martínez R.; Cuellar, M; Villena J.

Keywords: apoptosis, sesquiterpenes, cytotoxic activity, drimanes, cancer cell lines, Mitochondrial membrane permeability, caspasa-3 activity, nordrimanes

Abstract

Twelve drimanes, including polygodial (1), isopolygodial (2), drimenol (3), confertifolin (4), and isodrimenin (5), were obtained from natural sources. Semi-synthetic derivatives 6-12 were obtained from 1 and 2, and cytotoxic activity was evaluated in vitro against cancer cell lines (HT-29, MDA-MB231, DHF, MCF-7, PC-3, DU-145, and CoN). IC50 values were determined at concentrations of 12.5-100 mu M of each compound for 72 h. In addition, it was found that polygodial (1), 8, and 12 induced changes in mitochondrial membrane permeability in CoN, MCF-7, and PC-3 cells.

Más información

Título según WOS: Study on the Cytotoxic Activity of Drimane Sesquiterpenes and Nordrimane Compounds against Cancer Cell Lines
Título según SCOPUS: Study on the cytotoxic activity of drimane sesquiterpenes and nordrimane compounds against cancer cell lines
Título de la Revista: MOLECULES
Volumen: 19
Número: 11
Editorial: MDPI AG
Fecha de publicación: 2014
Página de inicio: 18993
Página final: 19006
Idioma: English
DOI:

10.3390/molecules191118993

Notas: ISI, SCOPUS