A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins

Choi, WI; Kamaly N.; Riol-Blanco, L; Lee, IH; Wu J.; Swami, A; Vilos C.; Yameen, B; Yu M.; Shi, JJ; Tabas I.; von Andrian, UH; Jon, S; Farokhzad OC.

Keywords: therapeutic proteins, Nanopartilces, thermosponge, solvent-free, biologics

Abstract

Protein therapeutics have gained attention recently for treatment of a myriad of human diseases due to their high potency and unique mechanisms of action. We present the development of a novel polymeric thermosponge nanoparticle for efficient delivery of labile proteins using a solvent-free polymer thermo-expansion mechanism with clinical potential, capable of effectively delivering a range of therapeutic proteins in a sustained manner with no loss of bioactivity, with improved biological half-lives and efficacy in vivo.

Más información

Título según WOS: A Solvent-Free Thermosponge Nanoparticle Platform for Efficient Delivery of Labile Proteins
Título según SCOPUS: A solvent-free thermosponge nanoparticle platform for efficient delivery of labile proteins
Título de la Revista: NANO LETTERS
Volumen: 14
Número: 11
Editorial: AMER CHEMICAL SOC
Fecha de publicación: 2014
Página de inicio: 6449
Página final: 6455
Idioma: English
DOI:

10.1021/nl502994y

Notas: ISI, SCOPUS