Method for producing recombinant proteins in the mammary glands of mammals by transforming the mammary gland epithelium with adeno-associated vectors

Sanchez O.; Toledo J.R.; Gonzalez Chavarria I.; Salgado E.; Shulz D.; Camacho F.; Cabezas O.; Hugues F.; Gonzalez M.; Salas A.; Montesino R.; Saavedra P.


The invention relates to a method that enables the production of recombinant proteins in the milk of non-transgenic mammals. The method is based on the direct transfer of the genetic information of interest to the cells forming the secretory mammary epithelium, by means of adeno-associated vectors. Using this method, it is possible to produce high levels of recombinant proteins in the milk of non-transgenic mammals during a complete lactation period. The method is scalable and enables sustained levels of expression to be achieved for periods of more than 100 days

Más información

Fecha de publicación: 2016