Assessment of the Relative Advantage of Various Artesunate-Based Combination Therapies by a Multi-Treatment Bayesian Random-Effects Meta-Analysis

Jansen, Frans H.; Lesaffre, Emmanuel; Penali, Louis K.; García-Zattera, María-José; Die-Kakou, Henri; Bissagnene, Emmanuel


Over the years, multiple articles on Artemisinin-based Combination Therapies (ACTs) were published, highlighting the relative advantages or drawbacks of these combinations. Many studies were comparative. Because none of the studies compare all combinations and methodology varies between studies, there is no homogeneity. A multitreatment Bayesian random-effects meta-analysis was designed to assess the relative effect of each combination therapy to artesunate + sulfadoxine-pyrimethamine (4 mg/kg/day for 3 days). By far the most attractive result for the variable adequate clinical and parasitological response at day 28 PCR corrected is given by the combination artemetherlumefantrine. Annual follow-up on the data published is intended to reveal the changes in the relative drug efficacy values of ACTs.

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Título de la Revista: The American Society of Tropical Medicine and Hygiene
Volumen: 77
Número: 6
Fecha de publicación: 2007
Página de inicio: 1005
Página final: 1009
Idioma: English