Comparative study of the anti-inflammatory activity and quali- and quantitative composition of triterpenoids between Ugni molinae leaves from ten genotypes.

Arancibia-Radich J, Peña-Cerda P, Jara D, Goity L, Valenzuela-Barra G, Silva X, Garrido, G, Delporte C, Seguel I.

Keywords: pentacyclic triterpenoids, hplc-dad, anti-inflammatory activity, Ugni molinae genotypes, mouse ear edema, TPA (12-O-tetradecanoylphorbol-13-acetate)


The aim of this study was to assess the differences in qualitative-quantitative composition of triterpenoids and total phenolic contents, together with anti-inflammatory activity of Ugni molinae leaves obtained from ten genotypes. The ethyl acetate (EAE) and ethanol extracts (ETE) were obtained and analyzed. The plant genotypes were grown under same soil and climate conditions and under same agronomic management; the leaves were also harvested under the same conditions. Anti-inflammatory activity was evaluated by mice ear edema induced by 12-O-tetradecanoylphorbol-13-acetate (TPA) at a single dose of 200 mg/kg BW of each extract. Composition of triterpenoids and total phenolic contents was determined by HPLC-DAD and Folin-Ciocalteu method, respectively. Ugni molinae leaves of different plant genotypes exhibited significant differences in regard to their anti-inflammatory activity, as well as in qualitative-quantitative composition of triterpenoids and total phenolic content.

Más información

Título de la Revista: Boletín Latinoamericano y del Caribe de Plantas Medicinales y Aromáticas
Volumen: 15
Número: 5
Editorial: Universidad de Santiago de Chile
Fecha de publicación: 2016
Página de inicio: 244
Página final: 287
Idioma: English
Financiamiento/Sponsor: FONDECYT 1130155


Notas: ISI