Acetylcholinesterase, a senile plaque component, affects the fibrillogenesis of amyloid-?-peptides

Alvarez, Alejandra; Bronfman, Francisca; P?rez, Cristi?n A.; Vicente, Mat?as; Garrido, Jorge; Inestrosa, Nibaldo C.


Acetylcholinesterase (AChE) colocalizes with amyloid-beta peptide (A beta) deposits present in the brain of Alzheimer's patients. Recent studies showed that A beta 1-40 can adopt two different conformational states in solution (an amyloidogenic conformer, A beta ac, and a non-amyloidogenic conformer, A beta nac) which have distinct abilities to form amyloid fibrils. We report here that AChE binds A beta nac and accelerates amyloid formation by the same peptide. No such effect was observed with A beta ac, the amyloidogenic conformer, suggesting that AChE acts as a 'pathological chaperone' inducing a conformational transition from A beta nac into A beta ac in vitro.

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Título de la Revista: Neuroscience Letters
Volumen: 201
Número: 1
Fecha de publicación: 1995
Página de inicio: 49
Página final: 52


Notas: ISI