Evaluation of 18F-FA-4 and 11C-pipzA-4 as radioligands for the in vivo evaluation of the high-affinity choline uptake system.

Gilissen, Christa; de Groot, Tjibbe J; Bronfman, Francesca; van Leuven, Fred; Verbruggen, Alfons M; Bormans, Guy M

Abstract

4,4'-Bis-1-hydroxy-2-(4-methylpiperidin-1-yl)ethyl-biphenyl (A-4), a tertiary amine analog of hemicholinium-3 (HC-3), is an inhibitor of the sodium-dependent high-affinity choline uptake (HACU) system. We have evaluated 4-[1-hydroxy-2-(4-(18)F-fluoromethylpiperidin-1-yl)ethyl]-4'-[1-hydroxy-2-(4-methylpiperidin-1-yl)ethyl]biphenyl ((18)F-FA-4) and 4-[1-hydroxy-2-(4-(11)C-methylpiperazin-1-yl)ethyl]-4'-[1-hydroxy-2-(4-methylpiperidin-1-yl)ethyl]biphenyl ((11)C-pipzA-4), an (18)F- and a (11)C-labeled derivative of A-4 as potential in vivo tracers for the HACU system.

Más información

Título de la Revista: JOURNAL OF NUCLEAR MEDICINE
Volumen: 44
Número: 2
Editorial: SOC NUCLEAR MEDICINE INC
Fecha de publicación: 2003
Página de inicio: 269
Página final: 275