Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones

Dagnino-Subiabre, A; CASSELS, BK; Baez, S; Johansson, AS; Mannervik, B; Segura-Aguilar, J

Abstract

Human glutathione transferase M2-2 prevents the formation of neurotoxic aminochrome and dopachrome by catalyzing the conjugation of dopamine and dopa o-quinone with glutathione. NMR analysis of dopamine and dopa o-quinone-glutathione conjugates revealed that the addition of glutathione was at C-5 to form 5-S-glutathionyl-dopamine and 5-S-glutathionyldopa, respectively. Both conjugates were found to be resistant to oxidation by biological oxidizing agents such as O-2, H2O2, and O-2(.-), and the glutathione transferase-catalyzed reaction can therefore serve a neuroprotective antioxidant function. (C) 2000 Academic Press.

Más información

Título según WOS: Glutathione transferase M2-2 catalyzes conjugation of dopamine and dopa o-quinones
Título de la Revista: BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS
Volumen: 274
Número: 1
Editorial: ACADEMIC PRESS INC ELSEVIER SCIENCE
Fecha de publicación: 2000
Página de inicio: 32
Página final: 36
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0006291X00930870
DOI:

10.1006/bbrc.2000.3087

Notas: ISI