Acute activation of Maxi-K channels (hSlo) by estradiol binding to the beta subunit

Valverde, MA; Rojas, P; Amigo, J; Cosmelli, D; Orio, P; Bahamonde, MI; Mann, GE; Vergara, C; Latorre, R


Maxi-K channels consist of a pore-forming alpha subunit and a regulatory beta subunit, which confers the channel with a higher Ca2+ sensitivity. Estradiol bound to the beta subunit and activated the Maxi-K channel (hSlo) only when both a and beta subunits were present. This activation was independent of the generation of intracellular signals and could be triggered by estradiol conjugated to a membrane-impenetrable carrier protein. This study documents the direct interaction of a hormone with a voltage-gated channel subunit and provides the molecular mechanism for the modulation of vascular smooth muscle Maxi-K channels by estrogens.

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Título según WOS: ID WOS:000082638300056 Not found in local WOS DB
Título de la Revista: SCIENCE
Volumen: 285
Número: 5435
Fecha de publicación: 1999
Página de inicio: 1929
Página final: 1931


Notas: ISI