Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents
The synthesis of new indazol-4,7-dione derivatives via 1,3-dipolar cycloaddition of diazomethane with 2,3-dimethyl-1,4-benzoquinone (2) and 1,4-naphthoquinone (7) followed by N-alkylation of the pyrazol nitrogen atom of the corresponding quinones (3) and (8) with methyl chloroacetate is described. A series of amides from esters (5) and (10) were also obtained. These compounds were tested in vitro as potential antitrypanosomal agents. Compounds (4) and (8) were found to have significant activity.
|Título según WOS:||Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents|
|Título según SCOPUS:||Synthesis of indazol-4,7-dione derivatives as potential trypanocidal agents|
|Título de la Revista:||JOURNAL OF HETEROCYCLIC CHEMISTRY|
|Fecha de publicación:||2002|
|Página de inicio:||1093|