Free radical scavengers, anti-inflammatory and analgesic activity of Acaena magellanica

Feresin, GE; Tapia, A; Gutierrez A.; Delporte C.; Erazo, NB; Schmeda-Hirschmann, G

Abstract

Extracts of the whole plant Acaena magellanica (Rosaceae) were assessed for anti-inflammatory, antipyretic and analgesic activity in animal models. At 600 mg kg-1, the global ethanolic extract (GEE), dichloromethane (DCM) and defatted methanol (MeOH) fractions showed a mild anti-inflammatory effect in the carrageenan-induced guinea-pig paw oedema. The GEE, DCM and defatted MeOH fractions significantly reduced inflammation by 43.2, 40.5 and 42.1%, respectively. The GEE did not showed any significant antipyretic activity in doses up to 600 mg kg-1. A 20% w/v infusion administered orally at 16 mL kg-1 presented analgesic effect in the acetic acid-induced abdominal constriction test in mice. The GEE and MeOH extract of A. magellanica showed free radical scavenging activity in the diphenylpicrylhydrazyl decolouration assay. Assay-guided isolation led to quercetin, Q-3-O-?-D-glucoside, Q-3-O-?-D-galactoside, ellagic acid and catechin as the free radical scavengers. The saponins tormentic acid 28-O-?-D-galactopyranoside and 28-O-?-D-glucopyranoside were isolated from the polar extract. The structures were determined by spectroscopic methods.

Más información

Título según WOS: Free radical scavengers, anti-inflammatory and analgesic activity of Acaena magellanica
Título según SCOPUS: Free radical scavengers, anti-inflammatory and analgesic activity of Acaena magellanica
Título de la Revista: JOURNAL OF PHARMACY AND PHARMACOLOGY
Volumen: 54
Número: 6
Editorial: OXFORD UNIV PRESS
Fecha de publicación: 2002
Página de inicio: 835
Página final: 844
Idioma: English
URL: http://doi.wiley.com/10.1211/0022357021779014
DOI:

10.1211/0022357021779014

Notas: ISI, SCOPUS