Ru(II)-Catalyzed Regioselective Hydroxymethylation of beta-Carbolines and Isoquinolines via C-H Functionalization: Probing the Mechanism by Online ESI-MS/MS Screening

Tokala, Ramya; Bora, Darshana; Sana, Sravani; Nachtigall, Fabiane M.; Santos, Leonardo S.; Shankaraiah, Nagula

Abstract

A Ru(II)-catalyzed regioselective C-H activation toward hydroxymethylation of beta-carbolines and isoquinolines as effective directing groups has been developed, and the mechanism was probed by using online electrospray ionization-tandem mass spectrometry. The introduction of the hydroxymethyl group in the biologically relevant molecules routed via C-H functionalization remains an important task. Gratifyingly, this protocol draws attention to the regioselective formation of monohydroxymethylated beta-carboline/isoquinoline products exclusively.

Más información

Título según WOS: Ru(II)-Catalyzed Regioselective Hydroxymethylation of beta-Carbolines and Isoquinolines via C-H Functionalization: Probing the Mechanism by Online ESI-MS/MS Screening
Título según SCOPUS: Ru(II)-Catalyzed Regioselective Hydroxymethylation of ?-Carbolines and Isoquinolines via C-H Functionalization: Probing the Mechanism by Online ESI-MS/MS Screening
Título de la Revista: Journal of Organic Chemistry
Volumen: 84
Número: 9
Editorial: American Chemical Society
Fecha de publicación: 2019
Página de inicio: 5504
Página final: 5513
Idioma: English
DOI:

10.1021/acs.joc.9b00454

Notas: ISI, SCOPUS - ISI