Mathematical modelling in genetic networks: Relationships between the genetic expression and both chromosomic breakage and positive circuits

Aracena, J; Ben Lamine, S; Mermet, MA; Cohen, O; Demongeot, J; IEEE Computer Society

Abstract

The genome has evolved since a primitive genome [1] until the present stare of the human genome dispatched along the 23 pails of chromosomes. This evolution has been ruled by the mutation process and also by the physiological and pathological reorganization of the genomic material inside or between the chromosomes, which are conditioning the genomic variability. This reorganization is starting at singular points on the short or long chromosomic arms, called crossing-over, or translocations, insertions, break points. In this paper, we tl ill show that these points, also called weak point ol hot spots of the genome are correlated, independently of their origin. In addition, we will give some propel ties of the interaction matrices in terms of the attractors (generalizing some results of ([2 - 5]) to case).

Más información

Título según WOS: ID WOS:000165991700018 Not found in local WOS DB
Título de la Revista: IEEE INTERNATIONAL SYMPOSIUM ON BIO-INFORMATICS AND BIOMEDICAL ENGINEERING, PROCEEDINGS
Editorial: IEEE COMPUTER SOC
Fecha de publicación: 2000
Página de inicio: 141
Página final: 149
DOI:

10.1109/BIBE.2000.889601

Notas: ISI