NO activates the olfactory cyclic nucleotide-gated conductance independent from cGMP in isolated rat olfactory receptor neurons

Schmachtenberg, O.; Díaz, J; Bacigalupo, J

Abstract

Nitric oxide (NO) is a putative neuronal messenger in the olfactory epithelium. We analysed the electrical responses of rat olfactory receptor neurones to NO stimulation in the whole-cell patch clamp mode and found that NO activates the cyclic nucleotide-gated conductance, independent from cyclic GMP. As NO may also open calcium-dependent potassium channels and raise cyclic GMP levels, it appears to act as a complex modulator of olfactory receptor neuron physiology in vivo. © 2003 Elsevier B.V. All rights reserved.

Más información

Título según WOS: NO activates the olfactory cyclic nucleotide-gated conductance independent from cGMP in isolated rat olfactory receptor neurons
Título según SCOPUS: NO activates the olfactory cyclic nucleotide-gated conductance independent from cGMP in isolated rat olfactory receptor neurons
Título de la Revista: BRAIN RESEARCH
Volumen: 980
Número: 1
Editorial: Elsevier
Fecha de publicación: 2003
Página de inicio: 146
Página final: 150
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0006899303029901
DOI:

10.1016/S0006-8993(03)02990-1

Notas: ISI, SCOPUS