Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives

Cuellar, MA; Salas C.; Cortes, MJ; Morello A.; Maya, JD; Preite, MD.

Abstract

The Diels-Alder reaction between two polygodial-derived dienes and simple quinones to yield substituted naphtho- and anthraquinones, is described. The in vitro trypanocide activity for the series was determined. Two of the new compounds showed an activity ten and two times higher, respectively, than nifurtimox and benznidazole, the medicines of choice for the treatment of the acute Chagas' disease. © 2003 Elsevier Science Ltd. All rights reserved.

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Título según WOS: Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives
Título según SCOPUS: Synthesis and in vitro trypanocide activity of several polycyclic drimane-quinone derivatives
Título de la Revista: BIOORGANIC & MEDICINAL CHEMISTRY
Volumen: 11
Número: 12
Editorial: PERGAMON-ELSEVIER SCIENCE LTD
Fecha de publicación: 2003
Página de inicio: 2489
Página final: 2497
Idioma: English
URL: http://linkinghub.elsevier.com/retrieve/pii/S0968089603001937
DOI:

10.1016/S0968-0896(03)00193-7

Notas: ISI, SCOPUS