Clinical presentation and treatment of primary lipodystrophies

VÍCTOR CORTÉS; JOSÉ LUIS SANTOS

Keywords: insulin resistance, lipodystrophy, leptin, adipose tissue, diabetes melllitus

Abstract

Lipodystrophies are a heterogeneous group of syndromes defined by a severe reduction of the adipose tissue. These can be congenital or acquired. Anatomically, they can be partial or generalized. The etiology of several lipodystrophies is well known. However, the cause of many others remains unknown. The commonest lipodystrophy worldwide is secondary to highly active anti-retroviral therapy in HIV-infected patients. By contrast, primary lipodystrophies (those not associated to any known disease or condition) are much less common and represent a diagnostic challenge. The major complications of lipodystrophies are metabolic, often resulting in severe insulin resistance, diabetes and dyslipidemia. No cure is available for lipodystrophies but the supplementation with recombinant leptin potently controls the metabolic abnormalities when there is a leptin deficiency. Herein, we review the clinical presentation, diagnostic process and therapeutic principles of the main primary lipodystrophy syndromes.

Más información

Título según WOS: Clinical presentation and treatment of primary lipodystrophies
Título según SCOPUS: Clinical presentation and treatment of primary lipodystrophies [Lipodistrofias primarias: Presentación clínica y diagnóstico]
Título según SCIELO: Lipodistrofias primarias: presentaci�n cl�nica y diagn�stico
Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 147
Número: 11
Editorial: SOC MEDICA SANTIAGO
Fecha de publicación: 2019
Página de inicio: 1449
Página final: 1457
Idioma: Spanish
DOI:

10.4067/s0034-98872019001101449

Notas: ISI, SCIELO, SCOPUS