Insights on the Role of Putative Muscle-Derived Factors on Pancreatic Beta Cell Function

Mizgier M.L.; Fernández-Verdejo R.; Cherfan J.; Pinget M.; Bouzakri K.; Galgani J.E.

Abstract

Skeletal muscle is a main target of insulin action that plays a pivotal role in postprandial glucose disposal. Importantly, skeletal muscle insulin sensitivity relates inversely with pancreatic insulin secretion, which prompted the hypothesis of the existence of a skeletal muscle-pancreas crosstalk mediated through an endocrine factor. The observation that changes in skeletal muscle glucose metabolism are accompanied by altered insulin secretion supports this hypothesis. Meanwhile, a muscle-derived circulating factor affecting in vivo insulin secretion remains elusive. This factor may correspond to peptides/proteins (so called myokines), exosomes and their cargo, and metabolites. We hereby review the most remarkable evidence encouraging the possibility of such inter-organ communication, with special focus on muscle-derived factors that may potentially mediate such skeletal muscle-pancreas crosstalk.

Más información

Título según WOS: Insights on the Role of Putative Muscle-Derived Factors on Pancreatic Beta Cell Function
Título según SCOPUS: Insights on the role of putative muscle-derived factors on pancreatic beta cell function
Título de la Revista: FRONTIERS IN PHYSIOLOGY
Volumen: 10
Editorial: FRONTIERS MEDIA SA
Fecha de publicación: 2019
Idioma: English
DOI:

10.3389/fphys.2019.01024

Notas: ISI, SCOPUS