Light-Activated Peptide-Based Materials for Sutureless Wound Closure

McTiernan C.D.; Cortes D.C.; Lazurko C.; Amrani S.; Rosales-Rojas R.; Zuñiga-Bustos M.; Sedlakova V.; Poblete H.; Stamplecoskie K.; Suuronen E.J.; Alarcon E.I.

Abstract

Using chemically modified extracellular matrix proteins, such as collagen, in combination with light for tissue bonding reduces inflammation and minimizes scarring. However, full length animal or recombinant human collagen proteins are difficult to isolate/produce. Thus, short biomimetic collagen peptides with properties equivalent to collagen at both structural and functional levels may be ideal building blocks for the development of remotely triggered adhesives and fillers. In this work, the conjugation of self-assembling collagen-like peptides to acrylate functionalized polyethylene glycol units yielded adhesive filler materials activated by visible light through the incorporation of a photosensitizer. When tested in a murine skin wound model, the photoactivated adhesives showed reduced scar formation and promoted epithelial regeneration.

Más información

Título según WOS: Light-Activated Peptide-Based Materials for Sutureless Wound Closure
Título según SCOPUS: Light-Activated Peptide-Based Materials for Sutureless Wound Closure
Título de la Revista: ACS APPLIED MATERIALS INTERFACES
Volumen: 11
Número: 48
Editorial: AMER CHEMICAL SOC
Fecha de publicación: 2019
Página de inicio: 45007
Página final: 45015
Idioma: English
DOI:

10.1021/acsami.9b18891

Notas: ISI, SCOPUS