Penicillin desensitization in allergic pregnant women with syphilis. Report of two cases

Alberto Fica; Daniel Muñoz; Rojas, Tamara.; Catalina Sanzana; Camila Muñoz

Keywords: pregnant women, Penicillins, hipersensitivity, desensitization, immunologic, Syphilis.


Syphilis during pregnancy has a high risk of congenital transmission with disastrous fetal consequences. Penicillin (PNC) is the only effective antimicrobial for the treatment of pregnant women with syphilis. Chilean guidelines do not consider desensitization to PNC in these women. We report two cases of pregnant women aged 32 and 23 years, with immediate allergy to PNC and syphilis who were safely and successfully desensitized using a four-hour intravenous protocol in the critical care unit and who subsequently received benzathine G PNC. An electronic survey was conducted among approximately 100 Clinical Pharmacists (CP) in the country. Of these, 16 answered and 13 reported having experience in drug desensitization, in at least five cases with PNC and none reported deaths or cardiorespiratory arrest. Desensitization to PNC can be carried out safely and in Chile, this alternative should be incorporated to the management of pregnant wo- men with syphilis and immediate allergy to PNC, instead of using erythromycin.

Más información

Título de la Revista: REVISTA MEDICA DE CHILE
Volumen: 148
Editorial: Sociedad Médica de Santiago
Fecha de publicación: 2020
Página de inicio: 344
Página final: 348
Idioma: Ingles