InsP(3)R, the calcium whisperer: Maintaining mitochondrial function in cancer

Lovy, Alenka; Foskett, J. Kevin; Cardenas, Cesar

Abstract

Mitochondrial metabolism is essential to fulfill the large demand for macromolecule biosynthesis in cancer. We recently identified low-level InsP(3)R-mediated Ca2+ transfer to mitochondria as an unexpected requirement for mitochondrial function. Here we reveal that its absence specifically targets cancer cells and causes necrosis at daughter cell separation during ongoing proliferation.

Más información

Título de la Revista: Molecular & Cellular Oncology
Volumen: 3
Número: 4
Editorial: TAYLOR & FRANCIS INC
Fecha de publicación: 2016
DOI:

10.1080/23723556.2016.1185563

Notas: WOS-ESCI