New potential strategies for Alzheimer's disease prevention: pegylated biodegradable dexibuprofen nanospheres administration to APPswe/PS1dE9

Sanchez-Lopez, Elena; Ettcheto, Miren; Antonia Egea, Maria; Espina, Marta; Cristina Calpena, Ana; Folch, Jaume; Camins, Antoni; Luisa Garcia, Maria


Dexibuprofen loaded pegylated poly(lactic-co-glycolic) nanospheres prepared by solvent diffusion method were designed to increase Dexibuprofen brain delivery reducing systemic side effects. Nanospheres exhibited a mean particle size around 200 nm (195.4 nm), monomodal population and negative surface charge. Drug loaded nanospheres showed a sustained release profile, allowing to modify the posology in vivo. Nanospheres were non-toxic neither in brain endothelial cells nor astrocytes and do not cause blood-brain barrier disruption. Nanospheres were able to partially cross the cells barrier and release the drug after co-culture in vitro experiments, increasing Dexibuprofen permeation coefficient. Behavioral tests performed in APPswe/PS1dE9 mice (mice model of familial Alzheimer's disease) showed that nanospheres reduce memory impairment more efficiently than the free drug. Developed nanospheres decrease brain inflammation leading to beta-amyloid plaques reduction. According to these results, chronical oral Dexibuprofen pegylated poly(lactic-coglycolic) nanosystems could constitute a suitable strategy for the prevention of neurodegeneration. (C) 2016 Elsevier Inc. All rights reserved.

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Título según WOS: ID WOS:000401089100038 Not found in local WOS DB
Volumen: 13
Número: 3
Editorial: Elsevier
Fecha de publicación: 2017
Página de inicio: 1171
Página final: 1182


Notas: ISI