Depression-like behavior is dependent on age in male SAMP8 mice

Perez-Caceres, D.; Ciudad-Roberts, A.; Rodrigo, M. T.; Pubill, D.; Camins, A.; Camarasa, J.; Escubedo, E.; Pallas, M.


Aging is associated with an increased risk of depression in humans. To elucidate the underlying mechanisms of depression and its dependence on aging, here we study signs of depression in male SAMP8 mice. For this purpose, we used the forced swimming test (FST). The total floating time in the FST was greater in SAMP8 than in SAMR1 mice at 9 months of age; however, this difference was not observed in 12-month-old mice, when both strains are considered elderly. Of the two strains, only the SAMP8 animals responded to imipramine treatment. We also applied the dexamethasone suppression test (DST) and studied changes in the dopamine and serotonin (5-HT) uptake systems, the 5-HT2a/2c receptor density in the cortex, and levels of TPH2. The DST showed a significant difference between SAMR1 and SAMP8 mice at old age. SAMP8 exhibits an increase in 5-HT transporter density, with slight changes in 5-HT2a/2c receptor density. In conclusion, SAMP8 mice presented depression-like behavior that is dependent on senescence process, because it differs from SAMR1, senescence resistant strain.

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Título según WOS: ID WOS:000319166600006 Not found in local WOS DB
Título de la Revista: BIOGERONTOLOGY
Volumen: 14
Número: 2
Editorial: Springer
Fecha de publicación: 2013
Página de inicio: 165
Página final: 176


Notas: ISI