Modulation of SIRT1 expression in different neurodegenerative models and human pathologies

Pallas, M.; Pizarro, J. G.; Gutierrez-Cuesta, J.; Crespo-Biel, N.; Alvira, D.; Tajes, M.; Yeste-Velasco, M.; Folch, J.; Canudas, A. M.; Sureda, F. X.; Ferrer, I.; Camins, A.


We examined the expression of SIRT1 in several experimental paradigms of human pathologies. We used a neuroblastoma cell line (B65), neuronal primary cultures (hippocampus and cerebellar granule cells) and in vivo approaches in rat and senescence murine models (SAM). Cell cultures and rats were treated with several well-know neurotoxins, i.e. rotenone, MPP+, kainate and 3-nitropropionic acid. Subsequently, SIRT1 expression was compared in these different paradigms of neurotoxicity. The pattern of expression of SIRT1 in proliferating cell cultures (B65) was different to that in quiescent cell cultures. In the murine model of senescence (senescence-accelerated mice prone, SAMP8), SIRT1 expression progressively decreased, while in the control strain (senescence-accelerated mice resistant, SAMR1) it increased. Finally, we studied human samples of Parkinson's disease (PD), dementia with Lewy bodies (DLB) and Huntington's diseases (HD). SIRT1 expression decreased dramatically in HD, but there were no significant changes in Parkinson-related illnesses. In conclusion, SIRT1 expression may be a good sensor of toxic neuronal processes. (C) 2008 IBRO. Published by Elsevier Ltd. All rights reserved.

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Título según WOS: ID WOS:000257677900021 Not found in local WOS DB
Título de la Revista: NEUROSCIENCE
Volumen: 154
Número: 4
Editorial: Elsevier
Fecha de publicación: 2008
Página de inicio: 1388
Página final: 1397


Notas: ISI