Activation of the calpain/cdk5/p25 pathway in the girus cinguli in Parkinson's disease

Alvira, Daniel; Ferrer, Isidre; Gutierrez-Cuesta, Javier; Garcia-Castro, Beatriz; Pallas, Merce; Camins, Antoni

Abstract

The mechanisms involved in neuronal loss in Parkinson's disease (PD) are not known, although recent studies performed in PD experimental models suggest that cdk5/p25 plays a predominant role. In the present study, we examined the gyrus cinguli of cases with PD and compared them with age-matched controls, and we demonstrated an activation of the calpain/cdk5 pathway. We found an increase in the p25/p35 immunoreactivity ratio and in the expression of transcription factor E2F-1. Our results implicate the cdk5/p25 pathway and re-entry into the cell cycle in the process of neuronal loss in patients with PD. (c) 2007 Elsevier Ltd. All rights reserved.

Más información

Título según WOS: ID WOS:000257646500008 Not found in local WOS DB
Título de la Revista: PARKINSONISM & RELATED DISORDERS
Volumen: 14
Número: 4
Editorial: ELSEVIER SCI LTD
Fecha de publicación: 2008
Página de inicio: 309
Página final: 313
DOI:

10.1016/j.parkreldis.2007.09.005

Notas: ISI