Flavopiridol: an antitumor drug with potential application in the treatment of neurodegenerative diseases

Pallas, M; Verdaguer, E; Jorda, EG; Jimenez, A; Canudas, AM; Camins, A


Several tines of evidence show that cyclin-dependent kinases (CDKs) contribute to neurodegenerative disorders such as Alzheimer's and Parkinson's diseases, and amyotrophic lateral sclerosis. Given their role in the neuronal apoptosis, the inhibition of CDKs by specific drugs such as flavopiridol. may be a valid therapeutic approach. Expression of CDKs was observed in rodent models of excitotoxicity and stroke, and CDK inhibitors showed neuroprotective effects. Flavopiridol may provide significant improvement in neurodegenerative diseases in humans. (C) 2004 Elsevier Ltd. All rights reserved.

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Título según WOS: ID WOS:000225481400027 Not found in local WOS DB
Título de la Revista: MEDICAL HYPOTHESES
Volumen: 64
Número: 1
Editorial: Penrith, Eng., Eden Press
Fecha de publicación: 2005
Página de inicio: 120
Página final: 123


Notas: ISI