Inhibition of CDKs: A strategy for preventing kainic acid-induced apoptosis in neurons

Verdaguer, E; Jorda, EG; Stranges, A; Canudas, AM; Jimenez, A; Sureda, FX; Pallas, M; Camins, A; Diederich, M

Abstract

Stimulation of ionotropic glutamate receptors are implicated in neurodegenerative diseases such as Alzheimer's and Parkinson's diseases. Recently this has been demonstrated in the expression of cell cycle proteins in vulnerable neurons in Alzheimer's disease. Thus, the aim of the present study was to evaluate the expression of cell cycle proteins in cerebellar granule cells after stimulation of AMPA/KA receptors and likewise to study the neuroprotective effects of CDK inhibitors. Our results demonstrated that after a treatment with CDK inhibitors, a significant decrease in apoptotic nuclei induced by kainic acid was found in the presence of flavopiridol and 3-ATA. We concluded that CDK activation is involved, at least, in part, in the pro-apoptotic effects of kainic acid.

Más información

Título según WOS: ID WOS:000189446300123 Not found in local WOS DB
Título de la Revista: ANNALS OF THE NEW YORK ACADEMY OF SCIENCES
Volumen: 1010
Editorial: Wiley
Fecha de publicación: 2003
Página de inicio: 671
Página final: 674
DOI:

10.1196/annals.1299.122

Notas: ISI