Assessment of the adrenergic effects of orphenadrine in rat vas deferens

Pubill, D; Canudas, AM; Pallas, M; Sureda, FX; Escubedo, E; Camins, A; Camarasa, J

Abstract

The peripheral adrenergic effects of orphenadrine, an antiparkinsonian drug, have been evaluated in the rat vas deferens to investigate whether these properties are the same as those of other phencyclidine ligands. In the low micromolar range, orphenadrine enhanced electrically-evoked and exogenous noradrenaline contractile responses in the epididymal portion of rat vas deferens. It also induced spontaneous activity that was inhibited by prazosin (1 mu M) but not by atropine (20 nM). It inhibited accumulation of [H-3]noradrenaline in rat vas deferens (IC50 = 14.2+/-2.3 mu M). Orphenadrine competitively inhibited [H-3]nisoxetine binding in rat vas deferens membranes (K-i = 1.05+/-0.20 mu M). It can be concluded that orphenadrine, at low micromolar concentrations, interacts with the noradrenaline reuptake system inhibiting its functionality and thus potentiating the effect of noradrenaline.

Más información

Título según WOS: ID WOS:000080229100011 Not found in local WOS DB
Título de la Revista: JOURNAL OF PHARMACY AND PHARMACOLOGY
Volumen: 51
Número: 3
Editorial: OXFORD UNIV PRESS
Fecha de publicación: 1999
Página de inicio: 307
Página final: 312
DOI:

10.1211/0022357991772303

Notas: ISI