Calcium mediates the activation of the inhibitory current induced by odorants in toad olfactory receptor neurons

Morales, B; Madrid, R; Bacigalupo, J


In toad olfactory neurons, a putrid odorant mixture inducing inhibitory responses increases Ca2+-activated K+ conductance, developing a hyperpolarizing receptor potential. Removal of extracellular Ca2+ or exposure to nifedipine reversibly reduced the inhibitory response, suggesting that odorants induce a Ca2+ influx. We show evidence for an odorant-induced Ca2+ current. Using confocal microscopy, it is shown that odorants induce a nifedipine-sensitive elevation of Ca2+ in the apical end of the cell. These results suggest an inhibitory mechanism in,which an apical Ca2+ influx causes an increase in internal Ca2+, opening Ca2+-activated K2+ channels that lead to membrane hyperpolarization.

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Título según WOS: ID WOS:A1997WJ55700035 Not found in local WOS DB
Título de la Revista: FEBS LETTERS
Volumen: 402
Número: 2-3
Editorial: Elsevier
Fecha de publicación: 1997
Página de inicio: 259
Página final: 264


Notas: ISI