Pathologic findings in reduction mammoplasty specimens: a surrogate for the population prevalence of breast cancer and high-risk lesions

Acevedo, Francisco; Armengol, V. Diego; Deng, Zhengyi; Tang, Rong; Coopey, Suzanne B.; Braun, Danielle; Yala, Adam; Barzilay, Regina; Li, Clara; Colwell, Amy; Guidi, Anthony; Cetrulo, Curtis L., Jr.; Garber, Judy; Smith, Barbara L.; King, Tari; et. al.


PurposeMammoplasty removes random samples of breast tissue from asymptomatic women providing a unique method for evaluating background prevalence of breast pathology in normal population. Our goal was to identify the rate of atypical breast lesions and cancers in women of various ages in the largest mammoplasty cohort reported to date.MethodsWe analyzed pathologic reports from patients undergoing bilateral mammoplasty, using natural language processing algorithm, verified by human review. Patients with a prior history of breast cancer or atypia were excluded.ResultsA total of 4775 patients were deemed eligible. Median age was 40 (range 13-86) and was higher in patients with any incidental finding compared to patients with normal reports (52 vs. 39 years, p=0.0001). Pathological findings were detected in 7.06% (337) of procedures. Benign high-risk lesions were found in 299 patients (6.26%). Invasive carcinoma and ductal carcinoma in situ were detected in 15 (0.31%) and 23 (0.48%) patients, respectively. The rate of atypias and cancers increased with age.ConclusionThe overall rate of abnormal findings in asymptomatic patients undergoing mammoplasty was 7.06%, increasing with age. As these results are based on random sample of breast tissue, they likely underestimate the prevalence of abnormal findings in asymptomatic women.

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Título según WOS: ID WOS:000459448500021 Not found in local WOS DB
Volumen: 173
Número: 1
Editorial: Springer
Fecha de publicación: 2019
Página de inicio: 201
Página final: 207


Notas: ISI