Abstract

Acute kidney injury (AKI) corresponds to a sudden reduction in renal function, and its diagnosis is based on an increase in serum creatinine or a decrease in diuresis. Both diagnostic criteria show slow kinetics and do not allow early intervention to modify the course of the pathology. Hence, it is essential to identify more early AKI biomarkers. In this protocol, a new biomarker, the fibroblast growth factor 23 (FGF23), will be studied for the detection of AKI caused by renal hypoperfusion due to transient and controlled ischemia during partial nephrectomy. Therefore, the objective of this protocol will be to evaluate the role of FGF23 in predicting the development of ischemic AKI. An observational and prospective study of a group of patients undergoing partial nephrectomies will be carried out. The control group will include patients undergoing abdominal surgeries. All patients will be measured creatinine and FGF23 before surgery and after 1, 24, and 72 hours of ischemia. Additionally, the duration of ischemia, episodes of hypotension, and estimated bleeding will be recorded. Preliminarily, 10 patients undergoing partial nephrectomies have been studied. Three developed AKI, but in all 10 patients, FGF23 increased in the first hour after ischemia. Although these results are promising, they should still be confirmed once the experimental protocol is concluded.