Hypoxia-related parameters during septic shock resuscitation: Pathophysiological determinants and potential clinical implications

Pavez, Nicolas; Kattan, Eduardo; Vera, Magdalena; Ferri, Giorgio; Daniel Valenzuela, Emilio; Alegria, Leyla; Bravo, Sebastian; Pairumani, Ronald; Santis, Cesar; Oviedo, Vanessa; Soto, Dagoberto; Ospina-Tascon, Gustavo; Bakker, Jan; Hernandez, Glenn; Castro, Ricardo

Abstract

Background: Assessment of tissue hypoxia at the bedside has yet to be translated into daily clinical practice in septic shock patients. Perfusion markers are surrogates of deeper physiological phenomena. Lactate-to-pyruvate ratio ( LPR) and the ratio between veno-arterial PCO2 difference and Ca-vO(2) (Delta PCO2/Ca-vO(2)) have been proposed as markers of tissue hypoxia, but they have not been compared in the clinical scenario. We studied acute septic shock patients under resuscitation. We wanted to evaluate the relationship of these hypoxia markers with clinical and biochemical markers of hypoperfusion during septic shock resuscitation.

Más información

Título según WOS: Hypoxia-related parameters during septic shock resuscitation: Pathophysiological determinants and potential clinical implications
Título de la Revista: ANNALS OF TRANSLATIONAL MEDICINE
Volumen: 8
Número: 12
Editorial: AME PUBL CO
Fecha de publicación: 2020
DOI:

10.21037/ATM-20-2048

Notas: ISI