Nanodiamonds and gold nanoparticles to obtain a hybrid nanostructure with potential applications in biomedicine

Pedroso-Santana, Seidy; Fleitas-Salazar, Noralvis; Sarabia-Sainz, Andrei; Silva-Campa, Erika; Angulo-Molina, Araceli; Pedroza-Montero, Martin; Riera, Raul


Using detonation nanodiamonds and fluorescent nitrogen-vacancy center nanodiamonds, linked to gold nanoparticles, we synthesized two hybrid nanostructures (HGDs) that were subsequently conjugated with a fluorophore. An amplification effect induced by the gold nanoparticles increased the emission spectrum of the fluorophore, maximizing the possibilities for imaging applications of these HGDs. The incubation of the nanostructures with HeLa cells produced no alteration of cell viability after 3 h and showed the presence of nanostructures in the cell cytoplasm at 24 h. These observations also indicate the potential biomedical use of the proposed HGDs.

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Título según WOS: ID WOS:000442633900001 Not found in local WOS DB
Título de la Revista: NANOTECHNOLOGY
Volumen: 29
Número: 43
Fecha de publicación: 2018


Notas: ISI